TNPSC Thervupettagam

GlowCas9 protein

December 17 , 2025 15 hrs 0 min 34 0
  • GlowCas9, a bioluminescent CRISPR-Cas9 protein engineered by the Bose Institute, Kolkata.
  • It fuses Cas9 with split nano-luciferase fragments from deep-sea shrimp, which emit light when Cas9 becomes active.
  • The system allows real-time monitoring of gene-editing activity inside living cells, tissues, and plant leaves without harming them.
  • GlowCas9 shows greater thermal stability and enhances homology-directed repair, improving precise DNA correction.
  • The technology enables theratracking, allowing scientists to observe therapeutic gene editing as it occurs in real time.

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