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Mild Mitochondrial Uncouplers
December 30 , 2025
15 hrs 0 min
19
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- Scientists are exploring “mild mitochondrial uncouplers” to help treat obesity by making cells burn more energy as heat.
- Mitochondria are cell structures that convert food into chemical energy called adenosine triphosphate (ATP), which powers muscles, the brain, and organs.
- In obesity, people consume more calories than they burn, so increasing energy use in cells may reduce weight.
- Earlier mitochondrial uncouplers were dangerous, causing overheating, organ failure, and death because they were too strong and uncontrolled.
- The new “mild” uncouplers increase energy use slowly, burning extra calories safely and reducing oxidative stress in cells.
- Mild uncouplers may also help prevent ageing, insulin resistance, and neurodegenerative diseases like dementia.
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