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Nobel Prize 2025 in Medicine
October 8 , 2025
15 hrs 0 min
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- Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi have been awarded the 2025 Nobel Prize in Physiology or Medicine.
- They discovered the concerning peripheral immune tolerance.
- It is a key mechanism preventing the immune system from attacking the body's own tissues.
- Their combined research proved that FOXP3 is the master regulator of regulatory T cells, confirming their function in maintaining immune self-tolerance.
- This discovery has laid the foundation for new treatments in cancer, autoimmune diseases, and transplant medicine, with some therapies currently in clinical trials.
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