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Protein RAD52
November 5 , 2025
16 hrs 0 min
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- A University of Iowa (USA) study revealed the unexpected structure of the DNA repair protein RAD52.
- RAD52 protects replicating DNA in dividing cells and helps cancer cells survive DNA damage.
- Cancers with DNA repair deficiencies rely on RAD52 as a backup for DNA repair.
- RAD52 is dispensable in healthy cells but essential for the survival of BRCA1 and BRCA2 deficient cancer cells.
- The study used cryogenic electron microscopy (CryoEM) to show RAD52 forms a double ring structure on DNA.
- Targeting RAD52 with inhibitors could provide new anti-cancer therapies with minimal effect on normal cells.
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